Cushing’s Disease

This test can help determine whether the cause of Cushing syndrome is rooted in the pituitary or somewhere else. For the test, blood samples are taken from the veins that drain the pituitary gland . An adrenal adenoma An autonomous aldosterone-producing adenoma is the most common cause of hyperaldosteronism. Aldosterone secretion is independent of sodium and potassium intake as well as of pituitary stimulation. Cortisol Cushing’s syndrome is characterized by an excess of cortisol, a glucocorticoid. Epinephrine and norepinephrine are produced by the adrenal medulla.

When the hypercortisolism results from an oversecretion of ACTH from the pituitary, the condition is called Cushing’s disease. The clinical presentation is the same for all of these conditions. The second of line of choice for unresectable or partially resectable adrenal or pituitary tumors would be radiation therapy. One form of radiotherapy is stereotactic radiosurgery wherein a single, large dose of radiation is targeted to the tumor, thereby reducing radiation exposure to surrounding tissues. Cushing syndrome involves the release of too much cortisol in the body.

Any unexplained fever without other symptoms should be a warning to the physical therapist of the need for medical follow-up. Therapists are more likely to treat people who have developed medication-induced Cushing’s syndrome. This condition occurs after these individuals have received a large dose of cortisol or cortisol derivitives. Exogenous steroids are administered for a number of inflammatory and other disorders such as asthma or rheumatoid arthritis. ACTH-dependent Cushing’s syndrome may result from hypersecretion of ACTH by the pituitary gland, secretion of ACTH by a nonpituitary tumor, such as small cell carcinoma of the lung or a carcinoid tumor , or administration of exogenous ACTH.

Sometimes doctors run a follow-up test to find out if excess cortisol is caused by Cushing’s syndrome or has a different cause. Sometimes a tumor on the adrenal gland itself makes too much cortisol. Adrenal tumors are most often benign but sometimes are cancerous. Other people develop endogenous Cushing’s syndrome because their bodies make too much cortisol. Several types of tumors can cause the body to make excess cortisol. The most common cause of Cushing’s syndrome is the long-term, high-dose use of the cortisol-like glucocorticoids.

Using a special microscope and fine instruments, a surgeon approaches the pituitary gland through a nostril or an opening made below the upper lip. Your doctor will probably kmst blog refer you to a center specializing in this type of surgery. Treatment depends on the cause and may include surgery, radiation, chemotherapy, or cortisol-reducing medicines.

It is a common clinical problem in neurology or neurosurgical units. Management of the client with Cushing’s is accomplished by removing the cause—hyperplasia of the gland. A low-sodium diet, regulation of fluid and electrolytes, and administration of a potassium-sparing diuretic such as aldactone help to decrease the symptoms. Because elevated glucose levels are common in the client with Cushing’s syndrome, the client often requires frequent checks of glucose levels and administration of insulin or oral antidiabetic medications. CT will immediately identify significant disease that may need urgent cancer surgery (e.g. adrenal cancer) or other investigation and management such as for small cell lung cancer. Also, it allows identification of major co-morbidities , which may guide further clinical care.

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